Reviewing toxicokinetics with a focus on metabolism of new psychoactive substances in the zebrafish (larvae) model

Zebrafish (Danio rerio) share around 70% of their genome with humans and many important enzymes for drug metabolism such as some cytochrome p450s have direct orthologs in zebrafish. To date, several studies showed a similar to general. Furthermore, although using adult fish model organism requires approval by an Ethics Committee, larvae until 120 h postfertilization does not necessarily need any at least the European Union. All these aspects seem be beneficial zebrafish (larvae) toxicokinetic so-called new psychoactive substances. These compounds are expected effects traditional drugs abuse but often listed controlled when they first appear on market. However, no information about toxicokinetics is available appear, which particularly critical concerning biotransformation. This knowledge example, developing urine-based screening procedures or predicting drug–drug interactions. focus article aims briefly introduce into topic context studies, will highlight route administration, consider this model. categorized under: Toxicology > New Psychoactive Substances Analytical